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ResearchOctober 20, 2026

Distillation, Self-Training, and the Fragility of Learned Chemical Reasoning

arXiv:2610.24199v1 Announce Type: new Abstract: Automating synthesis planning for small-molecule drug design requires chemical reasoners that are accurate as well as open to inspection and adaptation, yet frontier language models remain unreliable at predicting reaction outcomes…

Anagha Aneesh, Sebastian Ibarraran, Frank Hu, Jason Liu, Grant Rotskoff·arXiv — cs.AI
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  • 01.arXiv:2610.24199v1 Announce Type: new Abstract: Automating synthesis planning for small-molecule drug design requires chemical reasoners that are accurate as well as open to inspection and adaptation, yet frontier language models remain unreliable at predicting reaction outcomes…

This material is provided as an extended analytical summary.

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