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Distillation, Self-Training, and the Fragility of Learned Chemical Reasoning

arXiv:2610.24199v1 Announce Type: new Abstract: Automating synthesis planning for small-molecule drug design requires chemical reasoners that are accurate as well as open to inspection and adaptation, yet frontier language models remain unreliable at predicting reaction outcomes…

arXiv — cs.AIBy: Anagha Aneesh, Sebastian Ibarraran, Frank Hu, Jason Liu, Grant RotskoffOctober 20, 2026 (18 hours ago)
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  • arXiv:2610.24199v1 Announce Type: new Abstract: Automating synthesis planning for small-molecule drug design requires chemical reasoners that are accurate as well as open to inspection and adaptation, yet frontier language models remain unreliable at predicting reaction outcomes…
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Distillation, Self-Training, and the Fragility of Learned Chemical Reasoning

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